GlycoMira's proprietary SAGEs, or semi-synthetic glycosaminoglycosan ethers, target and inhibit multiple steps of inflammation. SAGEs block activation of the receptor for advanced glycation endproducts (RAGE), inhibit the proteolytic activity of cationic proteases, and also block P-selectin mediated leukocyte migration.
 References 1. Oottamasathien S, Jia W, McCoard L, Slack S, Zhang J, Skardal A, Job K, Kennedy TP, Dull RO, Prestwich GD. (2011) A murine model of inflammatory bladder disease: cathelicidin Peptide induced bladder inflammation and treatment with sulfated polysaccharides. Journal of Urology, Oct;186(4 Suppl):1684-92. 2. Zhang J, Xu X, Rao NV, Argyle B, McCoard L, Rusho WJ, Kennedy TP, Prestwich GD, Krueger G. (2011) Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea. PLoS ONE, Feb 9;6(2):e16658. |
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